„Burned-out“ tumor semenníka s metastázou do retroperitoneálnej lymfatickej uzliny

نویسندگان

  • Karol Kajo
  • Michal Kajo
  • Peter Zuzák
  • Emil Tvrdík
چکیده

Pojmom „burned-out tumour“ sa označuje zriedkavá klinická entita, ktorá sa prezentuje spontánnou a kompletnou regresiou testikulárneho nádoru bez predchádzajúcej liečby pri náleze metastáz v retroperitoneu, v mediastíne, v lymfatických uzlinách, v pľúcach alebo v pečeni. Opisujeme prípad 55-ročného pacienta s bolesťami v pravej driekovej oblasti, u ktorého bola CT vyšetrením zistená tumorózna masa v retroperitoneu (veľkosti 70 × 55 × 90 mm) a ultrasonografickým vyšetrením boli zaznamenané štrukturálne zmeny v oblasti dolného pólu pravého semenníka. U pacienta bola najprv vykonaná orchiektómia s histologickým nálezom jazvovitých alterácií v semenníku, bez jednoznačných nádorových zmien. Neskôr nasledovala radikálna extirpácia retroperitoneálneho nádoru, ktorý bol charakteru metastázy seminómu v lymfatickej uzline. Nález v semenníku bol preto prehodnotený na kompletne regredovaný nádor – „burned-out tumour“. Následne pacient podstúpil adjuvantnú chemoterapiu. V etiopatogenéze „burned-out“ nádorov sa uplatňujú predovšetkým imunologické faktory, menej sa zvažuje účasť ischémie. Prognóza „burned-out“ tumorov je v prípadoch seminomatóznych nádorov porovnateľná s prípadmi s primárnymi testikulárnymi nádormi zo zárodočných buniek.

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تاریخ انتشار 2014